Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | osteosarcoma tissues, cell lines (MG-63, U2OS, MNNG/HOS, hFOB 1.19) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 was up-regulated and functioned as an oncogene in osteosarcoma via RhoA and its downstream ROCKs.we confirmed that MALAT1 could regulate ROCK1/ROCK2 and their mediated metastasis and proliferation by working as a ceRNA mechanism via miR-144-3p.an overexpression of MALAT1 inhibited ROCK1/ROCK2 expression and its mediated metastasis and proliferation by working as a competitive endogenous RNA (ceRNA) via miR-144-3p. |
| Pubmed ID | 28938647 |
| Year | 2017 |
| Title | Long non-coding RNA MALAT1 for promoting metastasis and proliferation by acting as a ceRNA of miR-144-3p in osteosarcoma cells. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |