Basic Information
| LncRNA/CircRNA Name | BALR-6 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | B-lymphoblastic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Northern blot etc. |
| Sample | cell lines (MV, Reh, 697, Nalm-6, 70Z/3, HEK 293) |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of BALR-6 in murine bone marrow transplantation experiments caused a significant increase in early hematopoietic progenitor populations, suggesting that its dysregulation may cause developmental changes. Notably, the knockdown of BALR-6 resulted in global dysregulation of gene expression. The gene set was enriched for leukemia-associated genes, as well as for the transcriptome regulated by Specificity Protein 1 (SP1). We confirmed changes in the expression of SP1, as well as its known interactor and downstream target CREB1. Luciferase reporter assays demonstrated an enhancement of SP1-mediated transcription in the presence of BALR-6. These data provide a putative mechanism for regulation by BALR-6 in B-ALL |
| Pubmed ID | 26694754 |
| Year | 2015 |
| Title | BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia |
External Links
| Links for BALR-6 | GenBank HGNC NONCODE |
| Links for B-lymphoblastic leukemia | OMIM COSMIC |