Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Flow cytometry, etc. |
| Sample | ovarian cancer tissues, cell lines (SKOV3, OVCAR3, 3AO, HO8910) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 was overexpressed in ovarian cancer and associated to the poor prognosis. The down-regulation of MALAT1 inhibited cell proliferation, invasion and migration, arrested cell cycle progression in S phase and induced cell apoptosis by restraining the activation of Wnt/B-catenin signaling pathway in ovarian cancer cells. Three-year survival rate in high expression of MALAT1 was lower than that in low expression of MALAT1. |
| Pubmed ID | 29949143 |
| Year | 2018 |
| Title | Long non-coding RNA MALAT1 regulates ovarian cancer cell proliferation, migration and apoptosis through Wnt/?-catenin signaling pathway. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |