Basic Information
| LncRNA/CircRNA Name | BANCR |
| Synonyms | BANCR, LINC00586 |
| Region | GRCh38_9:69296682-69311111 |
| Ensemble | ENSG00000278910 |
| Refseq | NR_047671 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot etc. |
| Sample | PC tissues,cell lines(PANC-1, SW1990, HS766T, and CFPAC-1) |
| Expression Pattern | up-regulated |
| Function Description | We identified that BRAF-activated noncoding RNA was upregulated in pancreatic cancer tissues and cell lines, and BRAF-activated noncoding RNA was related to tumor metastasis and stage. BRAF-activated noncoding RNA reinforces proliferation, invasion, and migration in PANC-1 and SW1990 cells. Moreover, miR-195-5p was downregulated in both PC tissues and cell lines. Our results based on luciferase reporter, RIP-Ago2 and qRT-PCR assays, showed that miR-195-5p was a direct target of BRAF-activated noncoding RNA. |
| Pubmed ID | 31769353 |
| Year | 2019 |
| Title | LncRNA BANCR Promotes Pancreatic Cancer Tumorigenesis via Modulating MiR-195-5p/Wnt/?-Catenin Signaling Pathway |
External Links
| Links for BANCR | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |