Basic Information
| LncRNA/CircRNA Name | MAP3K20 |
| Synonyms | MLK7, MLTK, MLTKalpha, MLTKbeta, MRK, ZAK |
| Region | GRCh38_2:173075435-173268010 |
| Ensemble | ENSG00000091436 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP etc. |
| Sample | cell line (HGC27, SGC7901, MGC803, AGS and MKN-45, GES-1), gastric cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | MLK7-AS1 interacted with Dnmt1 and recruited it to miR-375 promotor, hyper-methylating miR-375 promotor and repressing miR-375 expression. Our findings demonstrate that knockdown of MLK7-AS1 by siRNA inhibits gastric cancer growth by epigenetically regulating miR-375. Knockdown of MLK7-AS1 by siRNA increased the expression of miR-375. MiR-375 wasfound to be an important tumor suppressor in gastric cancer bytargeting Janus kinase 2 (JAK2). |
| Pubmed ID | 29428732 |
| Year | 2018 |
| Title | Knockdown of long non-coding RNA MAP3K20 antisense RNA 1 inhibits gastric cancer growth through epigenetically regulating miR-375. |
External Links
| Links for MAP3K20 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |