Basic Information
| LncRNA/CircRNA Name | MAPKAPK5-AS1 |
| Synonyms | C12orf47 |
| Region | GRCh38_12:111839764-111842902 |
| Ensemble | ENSG00000234608 |
| Refseq | NR_015404 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, RIP, other |
| Sample | CRC tissues and cell lines (HCT116, SW480, HT-29, and DLD-1) |
| Expression Pattern | up-regulated |
| Function Description | Expression of MAPKAPK5-AS1 was significantly upregulated in 50 CRC tissues, and increased expression of MAPKAPK5-AS1 was found to be associated with greater tumor size and advanced pathological stage in CRC patients. Knockdown of MAPKAPK5-AS1 significantly inhibited proliferation and caused apoptosis in CRC cells. We also found that p21 is a target of MAPKAPK5-AS1. In addition, we are the first to report that MAPKAPK5-AS1 plays a carcinogenic role in CRC. |
| Pubmed ID | 30343528 |
| Year | 2019 |
| Title | Long Noncoding RNA MAPKAPK5-AS1 Promotes Colorectal Cancer Proliferation by Partly Silencing p21 Expression |
External Links
| Links for MAPKAPK5-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |