Basic Information
| LncRNA/CircRNA Name | MATN1-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:30718504-30726827 |
| Ensemble | ENSG00000186056 |
| Refseq | NR_034182 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Luciferase reporter assay, RIP, Western blot assay |
| Sample | Clinical samples,glioma cell lines (T98G, LN229, U87 and U251) and human embryonic kidney cell line HEK-293T |
| Expression Pattern | up-regulated |
| Function Description | MATN1-AS1 upregulation confirmed in glioma predicted poor clinical outcomes. Functionally, MATN1-AS1 knockdown restrained cell proliferation but stimulated apoptosis in vitro and repressed tumour growth in vivo. Mechanistic investigations validated that MATN1-AS1 functioned as a ceRNA for miR-200b/c/429 to upregulate CHD1 which was also verified to exert a growth-promoting role in glioma cells here. |
| Pubmed ID | 31667976 |
| Year | 2020 |
| Title | MATN1-AS1 Promotes Glioma Progression by Functioning as ceRNA of miR-200b/c/429 to Regulate CHD1 Expression |
External Links
| Links for MATN1-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |