Basic Information
| LncRNA/CircRNA Name | MCM3AP-AS1 |
| Synonyms | MCM3AP antisense RNA 1 |
| Region | GRCh38_21:46229217-46259390 |
| Ensemble | ENSG00000215424 |
| Refseq | NR_002776 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, luciferase reporter assay etc |
| Sample | liver cancer tissues, cell lines( GES-1, MGc-803, and SGC-7901) |
| Expression Pattern | up-regulated |
| Function Description | The level of MCM3AP-AS1 was significantly promoted in GC cell lines. Knockdown of MCM3AP-AS1 curbed cell proliferation and enhanced apoptosis in MGc-803 and SGC-7901 cells. Furthermore, the effect of the downregulation of MCM3AP-AS1 on cell proliferation and apoptosis was reversed by knockdown of miR-708-5p, which was targeted by MCM3AP-AS1 in vitro. |
| Pubmed ID | 32196596 |
| Year | 2020 |
| Title | Molecular Mechanisms of MCM3AP-AS1 Targeted the Regulation of miR-708-5p on Cell Proliferation and Apoptosis in Gastric Cancer Cells |
External Links
| Links for MCM3AP-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |