Basic Information
| LncRNA/CircRNA Name | MCM3AP-AS1 |
| Synonyms | MCM3AP antisense RNA 1 |
| Region | GRCh38_21:46229217-46259390 |
| Ensemble | ENSG00000215424 |
| Refseq | NR_002776 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qRT-PCR, Western blot analysis, Dual luciferase reporter assay, RIP |
| Sample | PC tissues,A pancreatic duct epithelial cell line (HPDE6-C7), human PC cell lines (PANC-1, BxPC-3, MIA PaCa-2, Capan-2, AsPC-1) as well as HEK-293 cell line |
| Expression Pattern | up-regulated |
| Function Description | MCM3AP-AS1 overexpression promoted proliferation, migration and invasion in PC cells. MCM3AP-AS1 silencing showed a suppressive effect on cell growth in PC cells. Moreover, MCM3AP-AS1 knockdown suppressed tumor growth in mice.MCM3AP-AS1 promoted FOXK1 expression by targeting miR-138-5p, and MCM3AP-AS1 facilitated growth and invasion in PC cells by FOXK1. |
| Pubmed ID | 31830901 |
| Year | 2019 |
| Title | Long Non-Coding RNA MCM3AP-AS1 Promotes Growth and Migration Through Modulating FOXK1 by Sponging miR-138-5p in Pancreatic Cancer |
External Links
| Links for MCM3AP-AS1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |