Basic Information
| LncRNA/CircRNA Name | MDC1-AS |
| Synonyms | MDC1-AS1, MDC1-AS |
| Region | GRCh38_6:30703067-30713184 |
| Ensemble | ENSG00000224328 |
| Refseq | NR_133647 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | glioma tissues, cell lines (U251, U87 MG and HEB) |
| Expression Pattern | down-regulated |
| Function Description | The results showed that the expression levels of lncRNA MDC1-AS and MDC1 were significantly downregulated in glioma tissues compared with normal brain tissues, and in glioma cell lines U87MG, U251 and HEB. Overexpression of MDC1-AS resulted in significant inhibition of cell proliferation and cell cycle in U87MG and U251. We also found that MDC1-AS expression was positively correlated with MDC1 expression. In addition, the inhibitory role of MDC1-AS was remarkably diminished when MDC1 was knockdown. |
| Pubmed ID | 27261595 |
| Year | 2016 |
| Title | MDC1-AS, an antisense long noncoding RNA, regulates cell proliferation of glioma. |
External Links
| Links for MDC1-AS | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |