Basic Information
| LncRNA/CircRNA Name | BANCR |
| Synonyms | BANCR, LINC00586 |
| Region | GRCh38_9:69296682-69311111 |
| Ensemble | ENSG00000278910 |
| Refseq | NR_047671 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Adriamycin (ADR) | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase assay |
| Sample | colorectal cancer tissues, cell lines (HCT116, LoVo, NCM460, HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | we found that BANCR and CSE1L expressions were upregulated in CRC tumor tissues. BANCR silencing suppressed cell proliferation and invasion capacity, increased apoptotic rate and potentiated cell sensitivity to ADR. BANCR acted as a molecular sponge of miR-203 to sequester miR-203 away from CSE1L in CRC cells. |
| Pubmed ID | 30144787 |
| Year | 2018 |
| Title | LncRNA BANCR promotes tumorigenesis and enhances adriamycin resistance in colorectal cancer. |
External Links
| Links for BANCR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |