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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	retinoblastoma
ICD-0-3	C69.2
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc.
Sample	RB tissues, retinal pigment epithelial cell line ARPE-19, human retinoblastoma (RB) cell lines HXO-RB44, Y79, and WERI-Rb1
Expression Pattern	up-regulated
Function Description	RB Cells Express the Higher Level of BANCR and Lower Level of miR-204-3p,The mRNA measurements showed that BANCR negatively modulate miR-204-3p expression via directly integration with it. Besides, miR-204-3p and Wnt/?catenin signalling pathway were found to participate in the oncogenic effects of BANCR on RB cell line by Hoechst staining, cell Counting Kit-8 (CCK-8) assay, wound healing assay, transwell assay, and Western blot analysis in vitro. In addition, an in vivo tumorigenesis experiment in nude mice injected with Y79 cells stably expressed sh-BANCR conformed in the effects of BANCR on RB. Taken together, the knockdown of BANCR inhibited cell proliferation, apoptosis, invasion, and migration in RB via targeting miR-204-3p, the mechanism may involve inhibiting Wnt/?-catenin signaling pathway
Pubmed ID	31482398
Year	2019
Title	Dysregulation of miR-204-3p Driven by the Viability and Motility of Retinoblastoma via Wnt/?-catenin Pathway In Vitro and In Vivo

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