Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Quantitative RT-PCR, other |
| Sample | Plasma |
| Expression Pattern | down-regulated |
| Function Description | Our results showed that the MEG3 expression was significantly down-regulated in GC,the expression levels of H19, MEG3 and miR-148a-3p were associated with some clinicopathological features of patients ,ROC analysis revealed that a combination of H19, MEG3 and miR-675-5p levels able to discriminate controls and GC subjects with 88.87% sensitivity and 85% specificity. |
| Pubmed ID | 30447342 |
| Year | 2019 |
| Title | Co-expression Profiling of Plasma miRNAs and Long Noncoding RNAs in Gastric Cancer Patients |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |