Basic Information
| LncRNA/CircRNA Name | BANCR |
| Synonyms | BANCR, LINC00586 |
| Region | GRCh38_9:69296682-69311111 |
| Ensemble | ENSG00000278910 |
| Refseq | NR_047671 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric adenocarcinoma |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot, MTT assay etc. |
| Sample | gastric adenocarcinoma tissues, cell lines (BGC823, SGC7901) |
| Expression Pattern | up-regulated |
| Function Description | BANCR expression was significantly up-regulated in gastric tumor tissues and gastric cell lines. Down-regulation of BANCR inhibited gastric cancer cell growth and promoted cell apoptosis, and it also contributed to a significant decrease of NF-??1 (P50/105) expression and 3'UTR of NF-B1 activity. Overexpression of NF-??1 reversed the effect of BANCR on cancer cell growth and apoptosis. MiroRNA-9 (miR-9) targeted NF-B1, and miR-9 inhibitor also reversed the effects of BANCR on gastric cancer cell growth and apoptosis. |
| Pubmed ID | 26248136 |
| Year | 2015 |
| Title | BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-??1. |
External Links
| Links for BANCR | GenBank HGNC NONCODE |
| Links for gastric adenocarcinoma | OMIM COSMIC |