Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Genotyping etc. |
| Sample | blood |
| Expression Pattern | differential expression |
| Function Description | We found that MEG3 rs7158663 AA genotype, but not GA genotype, had significant increased colorectal cancer risk, compared with GG genotype. Further stratified analysis indicated that the increased risk was significantly correlated with individuals with age less than 60 and family history of cancer. However, there was no significant association between rs7158663 and colorectal tumor site and stage. |
| Pubmed ID | 26934323 |
| Year | 2016 |
| Title | Associations between polymorphisms of long non-coding RNA MEG3 and risk of colorectal cancer in Chinese |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |