Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cardia adenocarcinoma |
| ICD-0-3 | C16.0 |
| Methods | qPCR, Cell transfection, Cell proliferation assay etc. |
| Sample | GCA tissues, cell lines (MKN45, SGC7901, BGC823, and AGS) |
| Expression Pattern | down-regulated |
| Function Description | MEG3 and miR-770 was significantly downregulated in GCA patients and cell lines. Overexpression of MEG3 and miR-770 inhibited gastric cancer cell proliferation and invasion in vitro. Furthermore, the expression level of MEG3 and miR-770 was significantly increased in cancer cells after treated with 5-Aza-dC. The aberrant hypermethylation of proximal promoter and enhancer region of MEG3 was detected in GCA tissues. |
| Pubmed ID | 28345805 |
| Year | 2017 |
| Title | Promoter hypermethylation-mediated downregulation of miR-770 and its host gene MEG3, a long non-coding RNA, in the development of gastric cardia adenocarcinoma. |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for gastric cardia adenocarcinoma | OMIM COSMIC |