Basic Information
LncRNA/CircRNA Name | MEG3 |
Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
Region | GRCh38_14:100779410-100861031 |
Ensemble | ENSG00000214548 |
Refseq | NR_002766 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | autophagy0 | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | endometrial cancer |
ICD-0-3 | NA |
Methods | qPCR, Cell transfection, Western blot, MTT assay etc. |
Sample | endometrial carcinoma tissues, cell lines (ESC, HEC-1A and KLE) |
Expression Pattern | down-regulated |
Function Description | Significant downregulation of MEG3 was observed in EC samples compared to control, while the protein levels of Notch1 and Hes1 were both upregulated. Cell proliferation was obviously inhibited by MEG3 overexpression, while opposite improved result was obtained in MEG3 knockout cells. Interestingly, MEG3-induced changes could be reversed by Notch1 regulators. Moreover, MEG3 overexpressing tumors showed strongly repressed growth in vivo, along with Notch signaling inhibition. |
Pubmed ID | 27470401 |
Year | 2016 |
Title | LncRNA-MEG3 inhibits cell proliferation of endometrial carcinoma by repressing Notch signaling. |
External Links
Links for MEG3 | GenBank HGNC NONCODE |
Links for endometrial cancer | OMIM COSMIC |