Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non-functioning pituitary adenoma |
| ICD-0-3 | C75.1 |
| Methods | qPCR etc. |
| Sample | pituitary tumor tissues |
| Expression Pattern | down-regulated |
| Function Description | In the present study we investigated the mechanism underlying the absence of MEG3 expression in human clinically nonfunctioning pituitary tumors. No genomic abnormality was detected in the tumors examined. Instead, we found that two 5'-flanking regions, immediately in front of and approximately 1.6-2.1 kb upstream of the first exon, respectively, were hypermethylated in tumors without MEG3 expression compared with the normal pituitary. |
| Pubmed ID | 15644399 |
| Year | 2005 |
| Title | Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for non-functioning pituitary adenoma | OMIM COSMIC |