Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, MTT assay etc. |
| Sample | cell lines (HepG2 and HuH-7) |
| Expression Pattern | up-regulated |
| Function Description | In result we found that the DNC dependent overexpression of miR-29a and miR-185 can down-regulate the expression of DNMT1, 3A and 3B and subsequently overexpresses MEG3. |
| Pubmed ID | 26321746 |
| Year | 2015 |
| Title | Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer. |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |