Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Flow cytometry assay, MTT assay etc. |
| Sample | cell line (HepG2) |
| Expression Pattern | differential expression |
| Function Description | Ectopic expression of MEG3 inhibited HepG2 cell proliferation in vitro and in vivo, and also induced apoptosis. Ectopic expression of MEG3 increased ER stress-related proteins 78-kDa glucose-regulated protein (GRP78), inositol-requiring enzyme 1 (IRE1), RNA-dependent protein kinase-like ER kinase (PERK), activating transcription factor 6 (ATF6), C/EBP homologous protein (CHOP), caspase-3, as well as p53 and NF-kB expression accompanied by NF-kB translocation from the cytoplasm to the nucleus. Furthermore, inhibition of NF-kB with Bay11-7082 decreased p53 expression in the MEG3-transfected cells. |
| Pubmed ID | 27432655 |
| Year | 2016 |
| Title | Involvement of endoplasmic reticulum stress and p53 in lncRNA MEG3-induced human hepatoma HepG2 cell apoptosis. |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |