Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | peptide | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, MTT assay etc. |
| Sample | glioma tumors, cell lines (U251, U87 and A172) |
| Expression Pattern | down-regulated |
| Function Description | The levels of MEG3 expression were significantly decreased in glioma tissues compared with normal brain tissues. We found marked downregulation in high-grade glioma samples and to a lesser degree, decreased in low-grade glioma samples, as compared to normal brain tissues, which gave clues that MEG3 may be involved in the disease pathogenesis in glioma |
| Pubmed ID | 26676363 |
| Year | 2016 |
| Title | Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas. |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |