Detail

Basic Information

LncRNA/CircRNA Name	MEG3
Synonyms	MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1
Region	GRCh38_14:100779410-100861031
Ensemble	ENSG00000214548
Refseq	NR_002766

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	colorectal cancer
ICD-0-3	C19.9
Methods	Western blot, Luciferase reporter assay, in vitro knockdown etc.
Sample	cell lines (RKO, SW1116, HT29, HCT116,LoVo, SW620, SW480, 293 T), CRC tissue
Expression Pattern	down-regulated
Function Description	MEG3 was down-regulated in CRC tissues and CRC patients with lower MEG3 showed poorer overall survival and disease-free survival than those with higher MEG3 level.MEG3 over-expression represses CRC cells proliferation and migration in vivo and in vitro,while MEG3 knockdown leads to the enhanced proliferation and metastasis of CRC cells.In CRC cells, MEG3 over-expression is related to decreased Clusterin mRNA and the corresponding protein levels,and it also directly binds to Clusterin protein through its 732-1174 region.In further, Clusterin over-expression rescues the compromised abilities of proliferation and metastasis induced by MEG3 over-expression,suggesting that MEG3 inhibits the CRC progression through regulating the Clusterin activities.Additionally,we found that 1a,25-(OH)2D and vitamin D receptor (VDR) stimulate MEG3 expression in CRC cells through directly binding to its promoter.
Pubmed ID	29628342
Year	2018
Title	MEG3 Activated by Vitamin D Inhibits Colorectal Cancer Cells Proliferation and Migration via Regulating Clusterin.

External Links

Links for MEG3	GenBank HGNC NONCODE
Links for colorectal cancer	OMIM COSMIC