Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Cell transfection, Western blot, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | glioma tissues, cell lines (U251, U87, NHA) |
| Expression Pattern | down-regulated |
| Function Description | MEG3 was down-regulated and miR-19a was up-regulated in malignant glioma tissues and cell lines. MiR-19a represses the expression of PTEN and promotes glioma cell proliferation, migration and invasion. However, MEG3 could directly bind to miR-19a and effectively act as a competing endogenous RNA (ceRNA) for miR-19a to suppress tumorigenesis. |
| Pubmed ID | 28276316 |
| Year | 2017 |
| Title | Long Noncoding RNA MEG3 Suppresses Glioma Cell Proliferation, Migration, and Invasion By Acting As Competing Endogenous RNA of MiR-19a. |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |