Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Flow cytometry assay etc. |
| Sample | melanoma cell lines (A375, SK-MEL-1, B16, A2058, and HEMa-LP) |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of MEG3 greatly repressed melanoma cell migration and invasion ability. |
| Pubmed ID | 29781534 |
| Year | 2018 |
| Title | LncRNA MEG3 repressed malignant melanoma progression via inactivating Wnt signaling pathway |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |