Basic Information
| LncRNA/CircRNA Name | MIAT |
| Synonyms | NA |
| Region | GRCh38_22:26646428-26676475 |
| Ensemble | ENSG00000225783 |
| Refseq | NR_003491 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay |
| Sample | non small cell lung cancer tissues, cell lines (A549 and H1975) |
| Expression Pattern | up-regulated |
| Function Description | The role of over-expression MIAT in NSCLC. We confirmed that rs1061451 T>C (allele odds ratio = 0.22; P < 0.01) was associated with NSCLC. Furthermore, we constructed MIAT-centric ceRNA network, and three mRNAs (MYO1B, SGK1 and WNT9A) was identified as targets by MIAT via miR-133a-5p. |
| Pubmed ID | 29795987 |
| Year | 2018 |
| Title | The lncRNA Myocardial Infarction Associated Transcript-Centric Competing Endogenous RNA Network in Non-Small-Cell Lung Cancer |
External Links
| Links for MIAT | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |