Basic Information
| LncRNA/CircRNA Name | MIAT |
| Synonyms | NA |
| Region | GRCh38_22:26646428-26676475 |
| Ensemble | ENSG00000225783 |
| Refseq | NR_003491 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | pancreatic cancer tissues, cell lines (PATU-8988, BxPC-3, PANC-1, SW1990 and AsPC-1) |
| Expression Pattern | up-regulated |
| Function Description | MIAT expression was found remarkably increased and miR-133 expression was significantly decreased in PC tissues and PC cell lines. PC patients with high MIAT level had poor prognosis than that with low MITA level. The results exhibited that the inhibition of miR-133 expression reversed the inhibition effect of MIAT down-regulation in the growth, migration and invasion of PC cells. Our results suggest that the interaction of MIAT and miR-133 play a role in the proliferation and metastasis of pancreatic carcinoma. |
| Pubmed ID | 29772434 |
| Year | 2018 |
| Title | The Interaction of Long Non-Coding RNA MIAT and miR-133 Play a Role in the Proliferation and Metastasis of Pancreatic Carcinoma |
External Links
| Links for MIAT | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |