Basic Information
| LncRNA/CircRNA Name | MIAT |
| Synonyms | NA |
| Region | GRCh38_22:26646428-26676475 |
| Ensemble | ENSG00000225783 |
| Refseq | NR_003491 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | non-small-cell lung cancer tissues and 30 paracancerous tissues, cell line(A549, H1299, H460 and H520) |
| Expression Pattern | up-regulated |
| Function Description | The expression of MIAT and MMP2 were elevated, while miR-139-5p was decreased in NSCLC tissues and cell lines.MIAT directly interacted with miR-139-5p and miR-139- 5p targetedly suppressed MMP2 in NSCLC cells. |
| Pubmed ID | 32345777 |
| Year | 2020 |
| Title | The long non-coding RNA MIAT/miR-139-5p/MMP2 axis regulates cell migration and invasion in non-small-cell lung cancer. |
External Links
| Links for MIAT | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |