Basic Information
| LncRNA/CircRNA Name | BANCR |
| Synonyms | BANCR, LINC00586 |
| Region | GRCh38_9:69296682-69311111 |
| Ensemble | ENSG00000278910 |
| Refseq | NR_047671 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | osteosarcoma tissues, cell lines (HOS, Saos-2, U2OS, and MG-63) |
| Expression Pattern | down-regulated |
| Function Description | BANCR overexpression was observed in osteosarcoma cell lines and clinical specimens. Increased BANCR expression was significantly associated with large tumor size, positive distant metastasis, and advanced clinical stage. High BANCR expression in osteosarcoma was an independent predictor of poor survival. Downregulation of BANCR inhibited MG-63 cell proliferation and invasion and promoted cell apoptosis in vitro. |
| Pubmed ID | 27051014 |
| Year | 2016 |
| Title | Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma |
External Links
| Links for BANCR | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |