Basic Information
| LncRNA/CircRNA Name | MIAT |
| Synonyms | NA |
| Region | GRCh38_22:26646428-26676475 |
| Ensemble | ENSG00000225783 |
| Refseq | NR_003491 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | HCC tissues, normal liver cell line (LO2) and HCC cell lines (SMMC-7721, HepG2, PLC/PRF/5 and Huh7) |
| Expression Pattern | up-regulated |
| Function Description | In summary, our study demonstrated a novel HCC specific SA-LncRNA miat, and found that miat functions as a ceRNA for miR-22-3p to upregulate sirt1 in HCC cellular senescence. Furthermore, miat downregulation promoted the progression of senescence and activated the tumor suppressor pathway p53/p21 and p16/pRb, which promoted the production of SASP and contributed to tumor cell proliferation inhibition, resulting in inhibition of HCC tumorigenesis |
| Pubmed ID | 31503007 |
| Year | 2019 |
| Title | lncRNA miat functions as a ceRNA to upregulate sirt1 by sponging miR-22-3p in HCC cellular senescence |
External Links
| Links for MIAT | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |