Basic Information
| LncRNA/CircRNA Name | MIF-AS1 |
| Synonyms | NA |
| Region | GRCh38_22:23894426-23898930 |
| Ensemble | ENSG00000218537 |
| Refseq | NR_038911 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | cancerous and paired normal paracancerous tissues human mammary epithelial cell line (MCF-10A) ,human breast cancer cell lines(MCF-7, MDA-MB-231 and MDA-MB-468) |
| Expression Pattern | up-regulated |
| Function Description | MIF-AS1 was upregulated in BC tissues and cells.MIF-AS1 depletion inhibited BC cell proliferation, migration and epithelial-mesenchymal transition (EMT).MIF-AS1 regulated the level of Homeobox B8 (HOXB8) via binding to miR-1249-3p.Taken all together, our findings proved that MIF-AS1 acted as a ceRNA by modulating miR-1249-3p/HOXB8 axis in breast cancer. |
| Pubmed ID | 31097355 |
| Year | 2019 |
| Title | Long Non-Coding RNA MIF-AS1 Promotes Breast Cancer Cell Proliferation, Migration and EMT Process Through Regulating miR-1249-3p/HOXB8 Axis |
External Links
| Links for MIF-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |