Basic Information
| LncRNA/CircRNA Name | MIR100HG |
| Synonyms | MIR100HG, AGD1, linc-NeD125, lncRNA-N2 |
| Region | GRCh38_11:122028327-122556721 |
| Ensemble | ENSG00000255248 |
| Refseq | NR_024430 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute megakaryoblastic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | blood, cell lines (CMK, Meg-01, K562, HT1080 and 293T etc.) |
| Expression Pattern | up-regulated |
| Function Description | Here we report that lncRNAs MONC and MIR100HG are highly expressed in AMKL blasts. The transcripts were mainly localized in the nucleus and their expression correlated with the corresponding miRNA clusters. Knockdown of MONC or MIR100HG impeded leukemic growth of AMKL cell lines and primary patient samples. Our study reveals an unprecedented function of lncRNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia. However, both mature let-7 isoforms did not show a strong positive correlation with their lincRNA host genes, suggesting active LIN28- and/or miR-107-mediated suppression of let-7 in MONC- and MIR100HG-high expressing cells . |
| Pubmed ID | 25027842 |
| Year | 2014 |
| Title | LincRNAs MONC and MIR101HG act as oncogenes in acute megakaryoblastic leukemia. |
External Links
| Links for MIR100HG | GenBank HGNC NONCODE |
| Links for acute megakaryoblastic leukemia | OMIM COSMIC |