Basic Information
| LncRNA/CircRNA Name | miR143HG |
| Synonyms | CARMN |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, other |
| Sample | BCa tissues, e human BCa cell lines (J82, T24, and SW780) and human normal uroepithelial cells (SV-HUC-1) |
| Expression Pattern | down-regulated |
| Function Description | Mechanistically, miR143HG was identified to inhibit the level of miR-1275, whereas miR-1275 directly targeted AXIN2, a negative regulator of the Wnt/?-catenin pathway. Restoration of miR-1275 or knockdown of AXIN2 significantly rescued the proliferation, migration, and invasion abilities of BCa cells.? |
| Pubmed ID | 30471109 |
| Year | 2019 |
| Title | LncRNA miR143HG Suppresses Bladder Cancer Development Through Inactivating Wnt/?-catenin Pathway by Modulating miR-1275/AXIN2 Axis |
External Links
| Links for miR143HG | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |