Basic Information
| LncRNA/CircRNA Name | MIR155HG |
| Synonyms | NA |
| Region | GRCh38_21:25561909-25575168 |
| Ensemble | ENSG00000234883 |
| Refseq | NR_001458 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | LSCC tissues and adjacent normal tissues ,human LSCC cell lines (TU686, TU177 and AMC-HN-8) and 293T cells |
| Expression Pattern | up-regulated |
| Function Description | MIR155HG and miR-155-5p were significantly upregulated in LSCC tissues, and were associated with the TNM stage, pathological differentiation and lymph node metastasis.Moreover, the knockdown of MIR155HG and miR-155-5p inhibited the proliferation, migration and invasion of LSCC cells, whereas their overexpression exerted the opposite effects in vitro and MIR155HG overexpression promoted tumorigenesis in vivo.MIR155HG in the TGF-?-induced EMT of LSCC cells by regulating EMT markers through the miR-155/SOX10 axis. |
| Pubmed ID | 31081043 |
| Year | 2019 |
| Title | TGF-?-induced Long Non-Coding RNA MIR155HG Promotes the Progression and EMT of Laryngeal Squamous Cell Carcinoma by Regulating the miR-155-5p/SOX10 Axis |
External Links
| Links for MIR155HG | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |