Basic Information
| LncRNA/CircRNA Name | MIR17HG |
| Synonyms | NA |
| Region | GRCh38_13:91347820-91354579 |
| Ensemble | ENSG00000215417 |
| Refseq | NR_027349 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot etc |
| Sample | NSCLC tissues,cell line (H2170 and H2126) |
| Expression Pattern | down-regulated |
| Function Description | Moreover, overexpression of MIR17HG also led to downregulated Bach-1, the downstream target of miR-142-3p. Cell invasion and migration analysis showed that overexpression of MIR17HG and miR-142-3p led to inhibited cancer cell invasion and migration. In contrast, overexpression of Bach-1 played an opposite role and attenuated the effects of overexpressing MIR17HG and miR-142-3p. |
| Pubmed ID | 32228546 |
| Year | 2020 |
| Title | LncRNA MIR17HG Inhibits Non-Small Cell Lung Cancer by Upregulating miR-142-3p to Downregulate Bach-1 |
External Links
| Links for MIR17HG | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |