Basic Information
| LncRNA/CircRNA Name | BANCR |
| Synonyms | BANCR, LINC00586 |
| Region | GRCh38_9:69296682-69311111 |
| Ensemble | ENSG00000278910 |
| Refseq | NR_047671 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cells lines(NPA, BCPAP,TPC1,Nthy-ori3-1),PTC tissues |
| Expression Pattern | down-regulated |
| Function Description | BANCR was significantly correlated with lymph node metastasis.BANCR inhibited cancer cell proliferation and invasion, which was associated with the induction of cell-cycle G2/M phase arrest and increased apoptosis. BANCR-mediated PTC cell proliferation and migration. BANCR functions as a tumor suppressor during thyroid carcinogenesis. |
| Pubmed ID | 29675113 |
| Year | 2018 |
| Title | Downregulation of BANCR Promotes Aggressiveness in Papillary Thyroid Cancer via the MAPK and PI3K Pathways. |
External Links
| Links for BANCR | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |