Basic Information
| LncRNA/CircRNA Name | MIR210HG |
| Synonyms | NA |
| Region | GRCh38_11:565660-568457 |
| Ensemble | ENSG00000247095 |
| Refseq | NR_038262 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | RT-PCR, Western blot |
| Sample | CC tissues,cell lines (SiHa, C-33A, HeLa, HT-3 and C-4II) |
| Expression Pattern | up-regulated |
| Function Description | The upregulation of MIR210HG was associated with advanced FIGO stage, metastasis, and poor prognosis in CC patients. Function assays showed that MIR210HG inhibition significantly suppressed the proliferation, invasion, and epithelial-mesenchymal transition (EMT) processes in CC and reduced tumor growth in vivo. Mechanistically, we identified that MIR210HG might serve as a competing endogenous RNA (ceRNA) of miR-503-5p to relieve the repressive effect of miR-503-5p on TRAF4 expression in CC cells. |
| Pubmed ID | 32087604 |
| Year | 2020 |
| Title | MIR210HG promotes cell proliferation and invasion by regulating miR-503-5p/TRAF4 axis in cervical cancer |
External Links
| Links for MIR210HG | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |