Basic Information
| LncRNA/CircRNA Name | MIR31HG |
| Synonyms | NA |
| Region | GRCh38_9:21455642-21559669 |
| Ensemble | ENSG00000171889 |
| Refseq | NR_027054 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Dual luciferase reporter assay, Western blot, RIP |
| Sample | hepatocellular carcinoma tissues, cell lines ??MMC7721, HepG2, Huh7,SK-hep1, L02, HEK 293 T cell) |
| Expression Pattern | down-regulated |
| Function Description | We found that overexpression of MIR31HG obviously suppressed HCC proliferation and metastasis in vitro and in vivo, overexpression of MIR31HG significantly decreased the expression of microRNA-575 (miR-575). MIR31HG were downregulated in HCC cell lines andtissues and was associated with the poor survival of patients. |
| Pubmed ID | 30176933 |
| Year | 2018 |
| Title | Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression. |
External Links
| Links for MIR31HG | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |