Basic Information
| LncRNA/CircRNA Name | MIR31HG |
| Synonyms | MIR31HG, hsa-lnc-31, LncHIFCAR |
| Region | GRCh38_9:21455642-21559669 |
| Ensemble | ENSG00000171889 |
| Refseq | NR_027054 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, in vitro knockdown etc. |
| Sample | cell lines (A549, H2228, H1975,H1299), lung adenocarcinoma tissue |
| Expression Pattern | up-regulated |
| Function Description | MIR31HG was highly expressed in lung adenocarcinoma tissues and cell lines,and associated with clinical staging, N classification,M classification and differentiated degree.MIR31HG high-expression was an independent unfavorable prognostic factor for lung adenocarcinoma patients.Down-regulation of MIR31HG inhibited lung adenocarcinoma cells proliferation and blocked cell-cycle, but has no effect on cell.apoptosis.MIR31HG high-expression is an independent unfavorable prognostic factor for lung adenocarcinoma patients,and serves an oncogenic role to modulate lung adenocarcinoma cells proliferation and cell-cycle. |
| Pubmed ID | 29367106 |
| Year | 2018 |
| Title | LncRNA MIR31HG overexpression serves as poor prognostic biomarker and promotes cells proliferation in lung adenocarcinoma. |
External Links
| Links for MIR31HG | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |