Basic Information
| LncRNA/CircRNA Name | MIR4435-2HG |
| Synonyms | NA |
| Region | GRCh38_2:111036776-111523376 |
| Ensemble | ENSG00000172965 |
| Refseq | NR_015395 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blot, Luciferase reporter analysis, RIP, RNA-seq |
| Sample | Blood,lung cancer cell lines H1770, A549, H1975, H596, H1299, H1650, and normal lung epithelial cell line BEAS2B |
| Expression Pattern | up-regulated |
| Function Description | lncRNA MIR4435-2HG was highly expressed in lung cancer tissues, especially in nonsmall cell lung cancer (NSCLC). A consistent result was obtained in lung cancer cells. Functional experiments showed that knockdown of MIR4435-2HG reduced the proliferation and migration ability of NSCLC cells.MIR4435-2HG was identified as an miRNA sponge for TGF-?1 and thus activated TGF-? signaling. |
| Pubmed ID | 31875359 |
| Year | 2020 |
| Title | LncRNA MIR4435-2HG-mediated Upregulation of TGF-?1 Promotes Migration and Proliferation of Nonsmall Cell Lung Cancer Cells |
External Links
| Links for MIR4435-2HG | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |