Basic Information
| LncRNA/CircRNA Name | MIR503HG |
| Synonyms | MIR503HG, H19X, MIR503HG2 |
| Region | GRCh38_X:134543337-134546632 |
| Ensemble | ENSG00000223749 |
| Refseq | NR_024607 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | anaplastic large cell lymphoma |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | cell lines (SR-786, KARPAS, MAC-1 and FePD) |
| Expression Pattern | up-regulated |
| Function Description | MIR503HG (miR-503 host gene) was highly expressed in ALK-negative cell lines and was significantly upregulated in tumors in mice formed from ALK-negative ALCL cell lines.Depletion of MIR503HG suppressed tumor cell proliferation in vivo and in vitro;conversely, its overexpression enhanced tumor cell growth. MIR503HG-induced proliferation was mediated by the induction of microRNA-503 (miR-503) and suppression of Smurf2, resulting in stabilization of the tumor growth factor-B receptor (TGFBR) and enhanced tumor cell growth. Collectively, these findings support a potential role for MIR503HG in cancer cell proliferation through the miR-503/Smurf2/TGFBR axis and indicate that MIR503HG is a potential marker in ALK-negative ALCL. |
| Pubmed ID | 29758012 |
| Year | 2018 |
| Title | The Long Non-Coding RNA MIR503HG Enhances Proliferation of Human ALK-Negative Anaplastic Large-Cell Lymphoma. |
External Links
| Links for MIR503HG | GenBank HGNC NONCODE |
| Links for anaplastic large cell lymphoma | OMIM COSMIC |