Basic Information
| LncRNA/CircRNA Name | MIR600HG |
| Synonyms | NA |
| Region | GRCh38_9:123109494-123115477 |
| Ensemble | ENSG00000236901 |
| Refseq | NR_026677 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Oxaliplatin (Oxa) | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | colorectal cancer tumour tissues, cell lines(HcoEpiC, Caco2) |
| Expression Pattern | down-regulated |
| Function Description | We detected down-regulated expression of long non-coding RNA (lncRNA) MIR600HG in CRC specimens and cell lines compared with normal controls, and the expression level of MIR600HG was inversely correlated with the overall survival of CRC patients. The inhibition of MIR600HG stimulated CRC cell metastasis and chemoresistance. |
| Pubmed ID | 32270866 |
| Year | 2020 |
| Title | MIR600HG suppresses metastasis and enhances oxaliplatin chemosensitivity by targeting ALDH1A3 in colorectal cancer |
External Links
| Links for MIR600HG | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |