Basic Information
| LncRNA/CircRNA Name | MLK7-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | CRC tissue, Human colonic epithelial cells (HCoEpiC) and CRC cells (SW480, HCT116, LOVO and DLD-1) |
| Expression Pattern | up-regulated |
| Function Description | The results of reverse transcription-quantitative polymerase chain reaction (RT qPCR) revealed a significant upregulation of MLK7 AS1 in both CRC tissue samples and cell lines. In addition, a positive correlation was observed between increased MLK7-AS1 expression and several clinicopathological factors in patients with CRC. Importantly, MLK7-AS1 knockdown suppressed CRC cell proliferation and promoted G1/G0 phase arrest and apoptosis in vitro, whereas MLK7-AS1 overexpression exhibited opposite effects. Consistently, decreased MLK7-AS1 expression inhibited tumor growth in vivo. Furthermore, RT-qPCR and western blot assays revealed that p21 may be a potential downstream target of MLK7-AS1. To the best of the authors' knowledge, this is the first study to report that MLK7-AS1 has potential as a biomarker and may promote proliferation in CRC partially through downregulating p21 expression |
| Pubmed ID | 30535460 |
| Year | 2019 |
| Title | Long non coding RNA MLK7 AS1 promotes proliferation in human colorectal cancer via downregulation of p21 expression |
External Links
| Links for MLK7-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |