Basic Information
| LncRNA/CircRNA Name | MNX1-AS1 |
| Synonyms | CCAT5 |
| Region | GRCh38_7:157010805-157016426 |
| Ensemble | ENSG00000243479 |
| Refseq | NR_038835 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blotting, Luciferase assays, RIP |
| Sample | GC tissues,MGC803, SGC7901, BGC823, HEK-293?? and GES-1 cell lines ,SGC7901, SGC803, GES-1 and HEK-293?? cells |
| Expression Pattern | up-regulated |
| Function Description | MNX1-AS1 displayed obvious upregulation in GC tissue samples and cell lines, and ectopic expression of MNX1-AS1 predicted poor clinical outcomes for patients with GC. Overexpressed MNX1-AS1 expression promoted proliferation, migration and invasion of GC cells markedly, whereas decreased MNX1-AS1 expression elicited the opposite effects. Consistent with the in vitro results, MNX1-AS1 depletion effectively inhibited the growth of xenograft tumour in vivo. Mechanistically, TEAD4 directly bound the promoter region of MNX1-AS1 and stimulated the transcription of MNX1-AS1. Furthermore, MNX1-AS1 can sponge miR-6785-5p to upregulate the expression of BCL2 in GC cells. Meanwhile, MNX1-AS1 suppressed the transcription of BTG2 by recruiting polycomb repressive complex 2 to BTG2 promoter regions. |
| Pubmed ID | 31924214 |
| Year | 2020 |
| Title | TEAD4 Modulated LncRNA MNX1-AS1 Contributes to Gastric Cancer Progression Partly Through Suppressing BTG2 and Activating BCL2 |
External Links
| Links for MNX1-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |