Basic Information
| LncRNA/CircRNA Name | MNX1-AS1 |
| Synonyms | MNX1 antisense RNA 1 |
| Region | GRCh38_7:157010805-157016426 |
| Ensemble | ENSG00000243479 |
| Refseq | NR_038835 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | RT-PCR, Dual luciferase reporter assay, Western blot analysis |
| Sample | Bladder cancer cells (T24, 5637, UM-UC-3 and BIU-3) |
| Expression Pattern | up-regulated |
| Function Description | Reduced expression of MNX1-AS1 could suppress cell proliferation, migration, invasion, and epithelial-mesenchymal transition in bladder cancer cells, whereas overexpression of MNX1-AS1 resulted in the opposite effects.MNX1-AS1 functions as a sponge to miR-218-5p to modulate RAB1A expression in bladder cancer. |
| Pubmed ID | 31843814 |
| Year | 2020 |
| Title | Long Noncoding RNA MNX1 Antisense RNA 1 Exerts Oncogenic Functions in Bladder Cancer by Regulating miR-218-5p/RAB1A Axis |
External Links
| Links for MNX1-AS1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |