Basic Information
| LncRNA/CircRNA Name | MNX1-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:157010805-157016426 |
| Ensemble | ENSG00000243479 |
| Refseq | NR_038835 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | lung cancer tissues, Human lung cancer cell lines (A549, SPC-A-1, H1975, and H1299) and human normal bronchial epithelial cell line (BEAS-2B) |
| Expression Pattern | up-regulated |
| Function Description | MNX1 AS1 was dramatically upregulated in lung cancer. MNX1 AS1 upregulation indicated poor prognosis in lung cancer patients. Functionally, MNX1 AS1 promoted lung cancer progression through regulating proliferation, migration, and invasion. Mechanistically, MNX1 AS1 was found to locate in the cytoplasm and interact with miR 527. Through inhibiting miR 527 availability, MNX1 AS1 facilitated BRF2 expression. Restoration of BRF2 rescued defects of proliferation, migration, and invasion caused by MNX1 AS1 knockdown. |
| Pubmed ID | 30618167 |
| Year | 2019 |
| Title | Long noncoding RNA MNX1-AS1 contributes to lung cancer progression through the miR-527/BRF2 pathway. |
External Links
| Links for MNX1-AS1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |