Basic Information
| LncRNA/CircRNA Name | MNX1-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:157010805-157016426 |
| Ensemble | ENSG00000243479 |
| Refseq | NR_038835 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot |
| Sample | human GC cell lines (HGC-27, MKN-45, SGC-7901, BGC-823) and one normal human gastric epithelial cell line (GES), GC tissues, adjacent tissues |
| Expression Pattern | up-regulated |
| Function Description | MNX1-AS1 expression in GC samples was significantly higher than that of the corresponding normal tissues. Meanwhile, MNX1- AS1 expression was associated with the overall survival time of GC patient. Moreover, the migration and invasion of GC cells were markedly promoted after MNX1-AS1 overexpression in vitro. The mRNA and protein expressions of CDKN1A were remarkably down-regulated after MNX1- AS1 overexpression. Furthermore, the expression level of CDKN1A was negatively correlated with the expression of MNX1-AS1 in GC tissues |
| Pubmed ID | 31210291 |
| Year | 2019 |
| Title | Long noncoding RNA MNX1-AS1 overexpression promotes the invasion and metastasis of gastric cancer through repressing CDKN1A |
External Links
| Links for MNX1-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |