Basic Information
| LncRNA/CircRNA Name | MORT |
| Synonyms | mortal obligate RNA transcript |
| Region | GRCh38_19:56477250-56500666 |
| Ensemble | ENSG00000166770 |
| Refseq | NR_036521 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | RT-qPCR, Western blot assay |
| Sample | Tumor and adjacent tissues,cell line RKO,blood |
| Expression Pattern | down-regulated |
| Function Description | The expression level of lncRNA MORT in tissue is linearly associated with plasma levels.lncRNA MORT is downregulated in colon cancer and is associated with low OS rate. Moreover, overexpression of lncRNA MORT inhibits migration and invasion of colon cancer cells by inhibiting TGF-? protein expression. |
| Pubmed ID | 31966041 |
| Year | 2020 |
| Title | Long Non-Coding RNA Mortal Obligate RNA Transcript Inhibits the Migration and Invasion of Colon Cancer Cells by Inactivating Transforming Growth Factor ?1 |
External Links
| Links for MORT | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |