Basic Information
| LncRNA/CircRNA Name | MRUL |
| Synonyms | DMTF1, DMP1, DMTF, MRUL, hDMP1 |
| Region | GRCh38_7:87152361-87196337 |
| Ensemble | ENSG00000135164 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | cell line (SGC7901) |
| Expression Pattern | up-regulated |
| Function Description | We show here that the lncRNA MRUL, was significantly upregulated in two multidrug-resistant GC cell sublines, SGC7901/ADR and SGC7901/VCR. Furthermore, the relative expression levels of MRUL in GC tissues were negatively correlated with in vitro growth inhibition rates of GC specimens treated with chemotherapeutic drugs and indicated a poor prognosis for GC patients. MRUL plays a positive role in the regulation of ABCB1 expression and is a potential target to reverse the MDR phenotype of GC MDR cell sublines. |
| Pubmed ID | 24958102 |
| Year | 2014 |
| Title | Long noncoding RNA MRUL promotes ABCB1 expression in multidrug-resistant gastric cancer cell sublines. |
External Links
| Links for MRUL | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |