Basic Information
| LncRNA/CircRNA Name | MSC-AS1 |
| Synonyms | NA |
| Region | GRCh38_8:71828167-72118393 |
| Ensemble | ENSG00000235531 |
| Refseq | NR_033652 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blot |
| Sample | OS tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | silencing MSC-AS1 inhibited OS biological behaviors by enhancing miR-142 to decrease CDK6 and inactivating the PI3K/AKT axis. |
| Pubmed ID | 32155139 |
| Year | 2020 |
| Title | Downregulated Long Non-Coding RNA MSC-AS1 Inhibits Osteosarcoma Progression and Increases Sensitivity to Cisplatin by Binding to MicroRNA-142 |
External Links
| Links for MSC-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |