Basic Information
| LncRNA/CircRNA Name | MSC-AS1 |
| Synonyms | Musculin antisense RNA1 |
| Region | GRCh38_8:71828167-72118393 |
| Ensemble | ENSG00000235531 |
| Refseq | NR_033652 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | kidney renal clear cell carcinoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blot analysis, Luciferase reporter assay |
| Sample | KIRC and normal adjacent tissues,normal kidney proximal tubular cell (HK-2) and KIRC cells 786-O, 769-P, A498, and CaKi-1 |
| Expression Pattern | up-regulated |
| Function Description | MSC-AS1 was dramatically upregulated in KIRC and correlated with dismal prognosis of KIRC patients.Knockdown of MSC-AS1 would suppress the proliferative and migratory properties of KIRC cells.MSC-AS1 was found to directly downregulate miR-3924 expression while miR-3924 directly downregulated WNT5A expression.MSC-AS1 regulates KIRC cell proliferation and migration via miR-3924/WNT5A/?-catenin axis. |
| Pubmed ID | 31916281 |
| Year | 2020 |
| Title | lncRNA MSC-AS1 Activates Wnt/?-catenin Signaling Pathway to Modulate Cell Proliferation and Migration in Kidney Renal Clear Cell Carcinoma via miR-3924/WNT5A |
External Links
| Links for MSC-AS1 | GenBank HGNC NONCODE |
| Links for kidney renal clear cell carcinoma | OMIM COSMIC |